DSPE-PEG-TCO (2000 Da) is a functionalized polyethylene glycol lipid conjugate engineered to enhance drug delivery systems. This amphiphilic polymer-lipid hybrid demonstrates unique capabilities in optimizing the bioavailability and targeted distribution of hydrophobic therapeutic compounds. Its molecular architecture combines a lipid anchor with a biocompatible PEG chain terminated by a trans-cyclooctene (TCO) group, enabling precise tissue-specific interactions while improving pharmacokinetic profiles. Researchers frequently employ this advanced biomaterial in developing nanoparticle formulations and ligand-directed therapeutic platforms for enhanced precision medicine applications.
