E197 Datasheet DC Chemicals

Description	E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models.
Cat.No	DC77492
Name	E197

Chemical Properties

CAS	2378515-04-7
Formula	C19H21CLN2O3S
MW	392.90
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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