NLRP3-IN-86 Datasheet DC Chemicals

Description	NLRP3-IN-86 (Compound 8a), a derivative of Songorine, is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS- and Nigericin-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation.
Cat.No	DC81158
Name	NLRP3-IN-86

Chemical Properties

CAS	2323-81-1
Formula	C7H13CLO2
MW	164.63
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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