Ganitumab Biosimilar (Anti-IGF1R / CD221 Reference Antibody ) Datasheet DC Chemicals
Description Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.
Cat.No A207
Name Ganitumab Biosimilar (Anti-IGF1R / CD221 Reference Antibody )

Chemical Properties

CAS 905703-97-1
Synonyms AMG 479; Human Anti-IGF1R Recombinant Antibody
pH value Corresponds to reference standard: PASS
Non-reduced CE-SDS >95%
SEC-HPLC 99.2%
Isoelectric Point 8.42
Bacterial Endotoxins Test <1 EU/mg as determined by the LAL method
Residual Proteins of Host Cell
Exogenous Residual DNA
Residual protein A
Biological Activity It is expressed from CHO. The heavy chain type is IgG1, and the light chain type is kappa. It has a predicted MW of 145.7 kDa.CHOK1-huIGF1R cells at 1×10^5 cell/well can bind Ganitumab, with the EC50 is 0.247 μg/mL.
Osmolality Corresponds to reference standard: PASS
Peptide mapping Corresponds to reference standard: PASS
N-terminal sequence Corresponds to reference standard: PASS

References

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