MS2133 Datasheet DC Chemicals

Description	MS2133 is a DOT1L PROTAC degrader. MS2133 promotes ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells (DC50: 56 nM and 25 nM, respectively), and reduces H3K79 methylation. MS2133 inhibits the growth of MLL-r leukemia cells and has anticancer activity.
Cat.No	DC77243
Name	MS2133

Chemical Properties

CAS
Formula	C58H66CLF3N14O11S2
MW	1291.81
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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