O-Desmethylcarvedilol Datasheet DC Chemicals

Description	O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol. O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively).
Cat.No	DC76742
Name	O-Desmethylcarvedilol

Chemical Properties

CAS	72956-44-6
Formula	C23H24N2O4
MW	392.45
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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