OICR41114 Datasheet DC Chemicals

Description	OICR41114 (PROTAC 4) is a WDR5-targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC50 and Dmax values of 40 nM and 49%, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner. OICR41114 is composed of target protein ligand Dimethyl-F-OICR-9429-COOH, E3 ligase ligand OICR-8268-acrylic acid and PROTAC linker Amino-PEG9-amine. The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid-amino-PEG9-amine).
Cat.No	DC77246
Name	OICR41114

Chemical Properties

CAS
Formula	C70H83CL2F6N9O15
MW	1475.36
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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