ZX079 Datasheet DC Chemicals

Description	ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC50 value of 0.035 nM and a CBP DC50 value of < 0.02 nM. ZX079 induces dose- and time-dependent degradation of BRD4 and CBP proteins through recruitment of the cereblon E3 ligase. ZX079 induces apoptosis in MV4-11 and MOLM-13 cells, reduces tumor growth in an acute myeloid leukemia xenograft model. ZX079 can be used for the research of acute myeloid leukemia. (Pink: BRD4 (BD1) and BRD4 (BD2) and CBP and p300 ligand ; Blue: Cereblon ligand ; Black: linker ).
Cat.No	DC81795
Name	ZX079

Chemical Properties

CAS	3094716-52-3
Formula	C25H32N6O
MW	432.56
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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