Cot-IN-4 Datasheet DC Chemicals

Description	Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases.
Cat.No	DC80469
Name	Cot-IN-4

Chemical Properties

CAS	1956355-97-7
Formula	C11H21CLN2O2
MW	248.75
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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