VLS-1272 Datasheet DC Chemicals

Description	VLS-1272 is an orally bioavailable, potent, ATP non-competitive, microtubule-dependent, and highly selective inhibitor of KIF18A. VLS-1272 is selective for KIF18A over other kinesins, with no inhibition of KIF11/Eg5, KIF18B, or KIFC1 at 100 µM, and IC50 of 280 nM against KIF19. VLS-1272 treatment results in mitotic defects leading to substantial, dose-dependent inhibition of tumor growth.
Cat.No	DC60831
Name	VLS-1272

Chemical Properties

CAS
Formula
MW
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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