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COA of Thalidomide-d4
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Description:
Thalidomide-d4 is a deuterium-enriched analog of the prototypic immunomodulatory drug thalidomide, featuring four strategically positioned deuterium substitutions. This isotopically labeled compound retains the parent molecule's ability to bind cereblon (CRBN) with high affinity (Kd ≈ 250 nM), thereby modulating the activity of the CUL4-RBX1-DDB1-CRBN E3 ubiquitin ligase complex.
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | >98% |
| CAS | 1219177-18-0 |
| Molecular Weight (MW) | 262.2541 |
| Molecular Formula | C13H6D4N2O4 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.