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Thalidomide-d4

  Cat. No.:  DC67348   Featured
Chemical Structure
1219177-18-0
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Field of application
Thalidomide-d4 is a deuterium-enriched analog of the prototypic immunomodulatory drug thalidomide, featuring four strategically positioned deuterium substitutions. This isotopically labeled compound retains the parent molecule's ability to bind cereblon (CRBN) with high affinity (Kd ≈ 250 nM), thereby modulating the activity of the CUL4-RBX1-DDB1-CRBN E3 ubiquitin ligase complex.
Cas No.: 1219177-18-0
Chemical Name: Thalidomide-d
Synonyms: Thalidomide-d4;4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;Thalidomide D4;3-Phthalimidoglutarimide-d4;A-Phthalimidoglutarimide-d4;Celgene-d4;Contergan-d4;Distaval-d4;Kevadon-d4;Myrin-d4;Thalidomide-d;MS-23690;(+/-)-Thalidomide-d4 (phenyl-d4);(+/-)-Thalidomide-d4;DTXSID40662207;CS-0019846;HY-14658S;J-004711;1219177-18-0;ARD157727D4;1ST157727D4;F91360;SCHEMBL410687;AKOS030243102;2-(2,6-Dioxopiperidin-3-yl)(~2~H_4_)-1H-isoindole-1,3(2H)-dione;DA-78381
SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
Formula: C13H6D4N2O4
M.Wt: 262.2541
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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