PKZ18 Datasheet DC Chemicals

Description	PKZ18 is a novel antibiotic that effectively suppresses bacterial growth, exhibiting MIC values ranging from 32 to 64 μg/mL against a broad spectrum of Gram-positive bacteria. Its mechanism involves the selective inhibition of glycyl-tRNA synthetase mRNA transcription and translation in vivo. PKZ18 specifically targets stem I specifier loops in Gram-positive bacteria, disrupting T-box-mediated transcriptional read-through of downstream genes. By interfering with codon-anticodon recognition, it blocks essential tRNA binding and demonstrates a high barrier to resistance development.
Cat.No	DC42762
Name	PKZ18

Chemical Properties

CAS	849658-87-3
Formula	C22H26N2O3S
MW	398.518444538116
Storage	0°C (short term), -20°C (long term), desiccated

References

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