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PKZ18

  Cat. No.:  DC42762   Featured
Chemical Structure
849658-87-3
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More than 5000 active chemicals with high quality for research!
Field of application
PKZ18 is a novel antibiotic that effectively suppresses bacterial growth, exhibiting MIC values ranging from 32 to 64 μg/mL against a broad spectrum of Gram-positive bacteria. Its mechanism involves the selective inhibition of glycyl-tRNA synthetase mRNA transcription and translation in vivo. PKZ18 specifically targets stem I specifier loops in Gram-positive bacteria, disrupting T-box-mediated transcriptional read-through of downstream genes. By interfering with codon-anticodon recognition, it blocks essential tRNA binding and demonstrates a high barrier to resistance development.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 849658-87-3
Chemical Name: Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[[5-methyl-4-[4-(1-methylethyl)phenyl]-2-thiazolyl]amino]carbonyl]-, (1R,2S,3R,4S)-rel-
Synonyms: Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[[5-methyl-4-[4-(1-methylethyl)phenyl]-2-thiazolyl]amino]carbonyl]-, (1R,2S,3R,4S)-rel-
SMILES: [C@]12([H])C[C@]([H])(CC1)[C@@H](C(NC1=NC(C3=CC=C(C(C)C)C=C3)=C(C)S1)=O)[C@H]2C(O)=O
Formula: C22H26N2O3S
M.Wt: 398.518444538116
Purity: >98%
Sotrage: 0°C (short term), -20°C (long term), desiccated
MSDS
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MSDS_26390_DC42762
COA
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