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SSR-240612 HCl
DC10799  (CAS:464930-42-5)
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Fields of Application :
SSR-240612 is a bradykinin B1 receptor antagonist potentially for the treatment of chronic pain.
CAS Number: 464930-42-5
Purity:

>98%

Molecular Weight: 793.42
Molecular Formula: C42H53ClN4O7S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: SSR-240612; SSR240612; SSR 240612
Chemical Name: D-Phenylalaninamide, (3S)-3-(1,3-benzodioxol-5-yl)-N-((6-methoxy-2-naphthalenyl)sulfonyl)-beta-alanyl-4-(((2R,6S)-2,6-dimethyl-1-piperidinyl)methyl)-N-methyl-N-(1-methylethyl)-, hydrochloride (1:1)
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
SSR240612 blocked tactile and cold allodynia at 3h (ID50=5.5and 7.1mg/kg,respectively) in glucose\fed rats but had no effect in control rats. The antagonist (10mg/kg) had no effect on plasma glucose and insulin, insulin resistance (HOMA index) and aortic superoxide anion production in glucose-fed rats.
References:
O=C(NC([C@@H](C1=CC=C(OCO2)C2=C1)CNS(=O)(C3=CC=C4C=C(OC)C=CC4=C3)=O)=O)[C@@H](CC5=CC=C(CN6[C@H](C)CCC[C@@H]6C)C=C5)N(C)C(C)C.[H]Cl
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