Home > Inhibitors & Agonists > GPCR > Protease-activated Receptor (PAR)
Cat. No. Product name CAS No.
DC10117 AC264613 Featured

AC264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation.

DC10879 AZ3451 Featured

AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2)

DC11742 AZ-8838

AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM.

DC11923 BMS-986120

BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.

DC8533 E5555 hydrobromide

E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031 μM respectively.

DC11741 GB-110

GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM.

DC11740 GB-88

GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.

DC7197 ML 161 Featured

Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.

DC8860 Vorapaxar Featured

Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

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