Home > Inhibitors & Agonists > Immunology/Inflammation > STING
Cat. No. Product name CAS No.
DC12367 2'3'-cGAMP Featured

2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.

1441190-66-4
DC11641 Cridanimod Featured

A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.

38609-97-1
DC11642 Cridanimod sodium Featured

Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.

58880-43-6
DC12321 STING agonist-1 trihydrochloride Featured

diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.

2138299-34-8
DC7404 DMXAA Featured

DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3.

117570-53-3
DC10876 H-151 Featured

H-151(H151) is a novel STING (stimulator of interferon genes) antagonist.

941987-60-6
DC10908 ML RR-S2 CDA Featured

ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).

1638241-89-0
DC11072 SINCRO

SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes.

1494619-28-1
DC26063 STING Agonist C11 Featured

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.

875863-22-2
DC11451 STING agonist compound 1 Featured

diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

2138299-33-7
DC11179 STING CDN agonist IFM Therapeutics

STING CDN agonist IFM Therapeutics is a synthetic cyclic dinucleotide (CDN) agonist of STING, stimulates potent immunity against cancer..

2197188-04-6
DC10960 STING inhibitor C-176 Featured

STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING

314054-00-7
DC10959 STING inhibitor C-178 Featured

STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).

329198-87-0
DC22331 STING agonist compound 3 Featured

STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

2138299-29-1
DC28012 c-Di-AMP(Cyclic-Di-AMP) ammonium salt Featured

Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].

54447-84-6
DC28013 Cyclic-di-GMP(c-di-GMP) Featured

Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.

61093-23-0
DC39030 SR-717 Featured

SR-717 is a non-nucleotide, small-molecule STING agonist and functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING.SR-717 functions as a direct cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) mimetic that induces the same “closed” conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

2375420-34-9
DC39031 MSA-2 Featured

MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2. Intracellular MSA-2 is "trapped" and accumulation drives MSA-2 dimerization, preferentially activating STING intratumorally. Orally dosed MSA-2 is well tolerated in mice, exhibiting STING-dependent antitumor activity, as monotherapy and combined with antibodies against PD1 (anti-PD1).

129425-81-6
DC39210 MSA-2 analogue Featured

MSA-2 analogue is an orally available human STING agonist.

2377885-95-3
DC39220 STING agonist compound 17 Featured

STING agonist compound 17 is a selective stimulator of interferon genes (STING) receptor agonist.

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