Home > Inhibitors & Agonists > Tyrosine Kinase > IGF-1R
Cat. No. Product name CAS No.
DC10112 AZD9362

AZD-9362 is dual IGF-IR/InsR inhibitor.

1905412-80-7
DC11760 BI 885578

BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.

DC3126 BMS754807 Featured

BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively.

1001350-96-4
DC2069 IGF-1R inhibitor GS1904529A

GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.

1089283-49-7
DC7549 NVP-ADW742 Featured

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

475488-23-4
DC4174 NVP-AEW541

NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.

475489-16-8
DC4105 Linsitinib(OSI-906) Featured

OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.

867160-71-2
DC7052 AG-1024 (Tyrphostin) Featured

AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.

65678-07-1
DC28921 I-OMe-Tyrphostin AG 538

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM.

1094048-77-7
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