Home > Inhibitors & Agonists > Apoptosis > Bcl-2
Cat. No. Product name CAS No.
DC9368 (S)-Gossypol (acetic acid)

(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).

1189561-66-7
DCC-073 Gossypol-acetic acid

>98%,Standard References

12542-36-8
DC11613 Mcl1-IN-26

A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays.

2056238-04-9
DC9768 A1155463 Featured

A-1155463 is a highly potent and selective BCL-XL inhibitor.

1235034-55-5
DC8475 A-1210477 Featured

A-1210477 is a potent and selective MCL-1 inhibitor.

1668553-26-1
DC9296 A-1331852

A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL.

1430844-80-6
DC2002 Venetoclax(ABT-199) Featured

ABT-199 is a Bcl-2-selective inhibitor with Ki < 0.010 nM.

1257044-40-8
DC4127 ABT-263 (Navitoclax) Featured

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.

923564-51-6
DC1022 ABT-737 Featured

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

852808-04-9
DC2015 AT-101 (AT101)

AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

866541-93-7
DC9709 BDA-366 Featured

BDA-366 is a Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.

1821496-27-8
DC9695 BH3I-1 Featured

BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL. BH3I-1 is an inhibitor of Bcl-xL.

300817-68-9
DC10966 BRD1991

BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity..

2235468-02-5
DC11219 BXI-72 Featured

BXI-72 (NSC334072) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM).

23491-52-3
DC9955 BCL6 inhibitor(CID5721353) Featured

CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor).

301356-95-6
DC10447 FX1 Featured

FX1 is a novel specific inhibitor of the B cell lymphoma 6 (BCL6).

1426138-42-2
DC10133 Gambogic Acid Featured

Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively.

2752-65-0
DCAPI1148 Gossypol

Gossypol

303-45-7
DC1066 HA14-1 Featured

HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM.

65673-63-4
DC8264 MM-41

MM41 is a quadruplex-interactive compound which binds strongly to the quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes.

DC7217 Obatoclax (GX15-070)

Obatoclax (GX15-070) is Bcl-2 homology domain-3 (BH3) mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).

803712-79-0
DC7233 Pifithrin-u Featured

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

64984-31-2
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