Home > Research Areas > Inflammation/Autoimmune Disease > Rheumatoid Arthritis
Cat. No. Product name CAS No.
DC11886 Adavivint

Adavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro

1467093-03-3
DC9406 Ampiroxicam

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

99464-64-9
DC5014 AVL-292

AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk currently being evaluated in a Phase 1b clinical trial in relapsed.

1202757-89-8
DC10425 AZD9056 hydrochloride

AZD9056 is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.

345303-91-5
DC11541 AZD-9567

AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis..

1893415-00-3
DC11542 AZD-9567 monohydrate

AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis..

1893415-64-9
DC11819 BMS-986142

BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM).

1643368-58-4
DC12030 BMS-986195

BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).

1912445-55-6
DC11154 CR6086

CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM.

DC8171 Decernotinib (VX-509,adelatinib)

Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.

944842-54-0
DC11398 Edicotinib(JNJ-40346527)

Edicotinib(JNJ-40346527)is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity.

1142363-52-7
DC10380 Evobrutinib

Evobrutinib is an inhibitor of Bruton's tyrosin kinase (Btk) inhibitor extracted from patent US20140162983 example 0174.

1415823-73-2
DC9942 GDC-0853(RG7845)

GDC-0853 is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.

1434048-34-6
DC7137 Filgotinib(GLPG0634)

GPLG0634 is a novel inhibitor of JAK1 and JAK2 with IC50 of 10nM and 28nM respectively.

1206161-97-8
DC9715 CHR5154

GSK3117391 (CHR5154) is a HDAC inhibitor.

1018673-42-1
DC8872 Iguratimod

Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.

123663-49-0
DC9389 INCB3344

INCB3344 is a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor; inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).

1262238-11-8
DC9011 Mizoribine

Mizoribine(NSC 289637; HE 69; β-Bredinin) is an immunosuppressive agents (IC50=100 uM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.

50924-49-7
DC9681 Pamapimod(R-1503)

Pamapimod(R-1503)is a novel p38 MAP kinase inhibitor.

449811-01-2
DC8168 Peficitinib(ASP015K,JNJ-54781532)

Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.

944118-01-8
DC10779 PF-06651600

PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM.

1792180-81-4
DC11373 Polmacoxib

Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII.

301692-76-2
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