Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Cytochrome P450 (CYPs)
Cat. No. Product name CAS No.
DC2710 Abiraterone (CB-7598)

Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM.

154229-19-3
DC8705 Carbosulfan

Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.

55285-14-8
DC10433 CDD3505

CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.

173865-33-3
DC10432 CDD3506

CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.

197913-15-8
DC2046 Cobicistat (GS-9350) Featured

Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

1004316-88-4
DC12079 DMU2105

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10, 742 nM for CYP1B1 and CYP1A1, respectively.

1821143-79-6
DC11473 DMU-2105(CYP1B1 inhibitor 7k) Featured

DMU-2105(CYP1B1 inhibitor 7k) is a potent and specific CYP1B1 inhibitor.

1031063-36-1
DC11474 DMU2139(CYP1B1 inhibitor 6j) Featured

DMU2139(CYP1B1 inhibitor 6j) is a potent and specific CYP1B1 inhibitor, with IC50s of 9, 795 nM for CYP1B1 and CYP1A1, respectively.

1821143-80-9
DC11329 Fadrozole (hydrochloride)

Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively).

102676-31-3
DC10967 HET0016

HET0016 (HET-0016) is a potent, selective inhibitor of CYP4A, potently inhibits the formation of 20-HETE with IC50 of 8.9 nM in human renal microsomes.

339068-25-6
DCAPI1146 Methoxsalen (Oxsoralen)

Methoxsalen (Oxsoralen)

298-81-7
DC2080 TMS Featured

TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.

24144-92-1
DC8008 TOK-001(Galeterone) Featured

TOK-001 is a multifunctional antiandrogen and CYP17 inhibitor(IC50=47 nM) in castration resistant prostate cancer (CRPC).

851983-85-2
DC28793 CYP11B2-IN-1

CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC50 of 142 nM.

1356479-78-1
DC29066 Quinidine sulfate dihydrate

Quinidine sulfate dihydrate is a potent and selective inhibitor of cytochrome P450db and inhibits amphetamine metabolism in vivo. Quinidine sulfate dihydrate enhances the cytotoxicity of vincristine (VCR) in tumor cells and especially in VCR-resistant sublines of P388 leukemia (P388/VCR) and human myelogenous leukemia.

6591-63-5
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