Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > DNA/RNA Synthesis
Cat. No. Product name CAS No.
DC4196 Bleomycin Sulfate

Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

9041-93-4
DC7959 BMH-21 Featured

BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.

896705-16-1
DC10430 COH29

COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with an IC50 of 8 μM in KB cell.

1190932-38-7
DC7810 CX-5461 Featured

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA, has no effect on Pol II, and possesses 250-to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

1138549-36-6
DC4197 Actinomycin D

Dactinomycin (also known generically as Actinomycin D ) is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces.

50-76-0
DC7664 Quarfloxin (CX-3543) Featured

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity.

865311-47-3
DC7725 TH 287 Featured

TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.

1609960-30-6
DC7726 TH 588 Featured

TH588 is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM.

1609960-31-7
DC28171 Rifalazil

Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB).

129791-92-0
DC28404 Caracemide

Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity.

81424-67-1
DC28439 Sorivudine

Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite drug. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis.

77181-69-2
DC28942 T-705RTP sodium

T-705RTP sodium, a nucleotide analog, selectively inhibits RNA-dependent RNA polymerase (RdRp) of the influenza virus. T-705RTP sodium competitively incorporates ATP/GTP and a single molecule of T-705RTP sodium is incorporated into a nascent RNA strand, which then inhibits subsequent virus RNA extension.

356783-10-3
DC28948 T-705RTP

T-705RTP is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC50 of 0.14 μM and a Ki of 1.52 μM. T-705RTP is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity.

740790-94-7
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