Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > DNA/RNA Synthesis
Cat. No. Product name CAS No.
DC4196 Bleomycin Sulfate

Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

9041-93-4
DC7959 BMH-21

BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.

896705-16-1
DC10430 COH29

COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with an IC50 of 8 μM in KB cell.

1190932-38-7
DC7810 CX-5461

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA, has no effect on Pol II, and possesses 250-to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

1138549-36-6
DC4197 Actinomycin D

Dactinomycin (also known generically as Actinomycin D ) is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces.

50-76-0
DC7664 Quarfloxin (CX-3543)

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity.

865311-47-3
DC7725 TH 287

TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.

1609960-30-6
DC7726 TH 588

TH588 is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM.

1609960-31-7
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