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Cat. No. Product name CAS No.
DC10616 3-TYP

3-TYP is a selective SIRT3 inhibitor.

120241-79-4
DC11585 MZ-242

A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM.

1862238-01-4
DC11587 SirReal1

A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM.

801227-82-7
DC8437 AGK2

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.

304896-28-4
DC7540 SIRT2 Inhibitor II, AK-7

AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).

420831-40-9
DC10744 Cambinol

Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.

14513-15-6
DC10579 CAY 10602

CAY10602 is a SIRT1 activator.

374922-43-7
DC11213 E1231

E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα).

1031195-19-3
DC10658 OSS-128167(SIRT6-IN-1)

OSS-128167 is a novel SIRT6 inhibitor.

887686-02-4
DC10002 Salermide

Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1.

1105698-15-4
DC8867 SirReal2

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

709002-46-0
DC7539 SIRT2 Inhibitor II, AK-1

SIRT2 Inhibitor II, AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3.

330461-64-8
DC12109 SIRT5 inhibitor

SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.

2166487-21-2
DC8900 SRT1720

SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM;SIRT3: EC1.5 > 300 μM).

925434-55-5
DC7300 SRT1720 HCl

SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3.

1001645-58-4
DC8412 SRT2104

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.

1093403-33-8
DC9710 SRT3025

SRT3025 is a sirt1 activator.

1231952-55-8
DC10629 SRT3025 HCl

SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

2070015-26-6
DC11156 SRTCX1002

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.

1203479-63-3
DC11157 SRTCX1003

SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay.

1203480-93-6
DC1065 Tenovin-1

Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

380315-80-0
DC7315 Tenovin-6

Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.

1011557-82-6
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