Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Polo-like Kinase (PLK)
Cat. No. Product name CAS No.
DC11635 Poloxin-2

A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM.

1807690-39-6
DC7083 Bi 2536 Featured

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM).

755038-02-9
DC10010 Centrinone

Centrinone is a selective and reversible inhibitor of polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole/centrosome assembly.

1798871-30-3
DC10011 Centrinone-B

Centrinone-B is a high affinity and selective PLK4 inhibitor (Ki = 0.59 nM).

1798871-31-4
DC8609 GW843682X Featured

GW843682X is a cell-permeable thiophene-benzimidazole compound and reversible PLK inhibitor

660868-91-7
DC8768 HMN-214 Featured

HMN-214(IVX214) is a potent PLK1 inhibitor an average IC50 of 0.12 μM.

173529-46-9
DC9594 Poloxin

Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain.

321688-88-4
DC7265 Rigosertib Featured

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.

1225497-78-8
DC7187 Volasertib(BI6727) Featured

Volasertib(BI6727) is a highly potent PLK1 inhibitor with an IC50 of 0.87 nM; shows 6- and 65-fold greater selectivity against Plk2 and Plk3.

755038-65-4
DC8598 PLK1 inhibitor GSK461364 Featured

GSK461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM.

929095-18-1
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