Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > DNA Alkylator/Crosslinker
Cat. No. Product name CAS No.
DC11163 AST-3424

AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent.

2097713-68-1
DC10434 Bisantrene

Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases.

78186-34-2
DC9095 Carboplatin

Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism.

41575-94-4
DC2099 Cisplatin Featured

Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity.

15663-27-1
DC9013 Cyclophosphamide

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

50-18-0
DC9014 Ifosfamide

Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.

3778-73-2
DC9050 Melphalan

Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA.

148-82-3
DC4182 Temozolomide

Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer.

85622-93-1
DC8935 Mitomycin C

Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.

50-07-7
DC9298 thiotepa

N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group.

52-24-4
DC5885 Oxaliplatin

Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the eff

61825-94-3
DC7689 Evofosfamide(TH-302) Featured

TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.

918633-87-1
DC10611 Trabectedin Featured

Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo.

114899-77-3
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