Home > Inhibitors & Agonists > Ras-Raf-MAPK-ERK > MEK (MAP2K)
Cat. No. Product name CAS No.
DC11959 PD 184161 Featured

A potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.

212631-67-9
DC10048 APS-2-79 Featured

APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM

2002381-25-9
DC9808 APS-2-79 hydrochloride Featured

APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM

2002381-31-7
DC1069 AZD6244 (Selumetinib,ARRY-142886) Featured

AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.

606143-52-6
DC7077 AZD8330(ARRY-424704; ARRY-704) Featured

AZD8330(ARRY-424704; ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.

869357-68-6
DC8401 BI-847325 Featured

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

1207293-36-4
DC5002 BIX02188 (BIX 02188) Featured

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

334949-59-6
DC5003 BIX02189 (BIX 02189)

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

1265916-41-3
DC2088 CI-1040 (PD184352) Featured

CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.

212631-79-3
DC4177 Cobimetinib(GDC-0973; XL518) Featured

GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway.

934660-93-2
DC7723 OTS-964 Featured

OTS964 is a novel TOPK(T–lymphokine-activated killer cell–originated protein kinase) inhibitor.

1338545-07-5
DC5100 PD 98059 Featured

PD 98059 is a selective inhibitor of MEK and blocker of MAPK

167869-21-8
DC1056 PD0325901 (PD325901) Featured

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.

391210-10-9
DC8744 PD318088

PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

391210-00-7
DC7808 Refametinib (BAY86-9766) Featured

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

923032-37-5
DC7489 RO5126766(CH5126766)

RO5126766(CH5126766) is a Raf/MEK dual kinase inhibitor.

946128-88-7
DC7308 TAK-733 Featured

TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc.

1035555-63-5
DC1099 Trametinib Featured

Trametinib is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

871700-17-3
DC7243 U0126 Featured

U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.

1173097-76-1
DC8473 Vacquinol-1 Featured

Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.

5428-80-8
DC7868 AS703026(Pimasertib) Featured

AS703026(Pimasertib) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.

1236699-92-5
DC7488 RO4987655 Featured

RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.

874101-00-5
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