Home > Inhibitors & Agonists > Apoptosis > MDM2-p53
Cat. No. Product name CAS No.
DC11637 MPK-09

A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.

1431884-83-1
DC11852 CTX-1

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.

501935-96-2
DC11669 CB-002

A novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.

61034-15-9
DC11865 DS-5272

A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM.

1235575-97-9
DC11834 AM-6761

A potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.

1584732-36-4
DC11836 AM-8735

A potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.

1429386-01-5
DC11830 WK-298

A potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively..

1067654-70-9
DC11837 RO-5963

A potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.

1416663-77-8
DC11725 BI-0252

A potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM.

1818291-27-8
DC11727 RO-2468

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.

1360821-21-1
DC11728 RO-5353

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.

1360821-61-9
DC11835 AM-8553

A potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.

1352064-70-0
DC11833 TDP-665759

A small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.

787632-66-0
DC11832 NU-8165

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM..

849723-20-2
DC11831 NU-8231

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay.

878022-36-7
DC9793 AMG232

AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells .

1352066-68-2
DC10657 COTI-2

COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation.

1039455-84-9
DC11726 DS-3032b

DS-3032b is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.

1398568-47-2
DC10613 Siremadlin (NVP-HDM201)

HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity.

1448867-41-1
DC7175 JNJ-26854165 (Serdemetan)

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.

881202-45-5
DC10958 MB710

MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro..

2230044-57-0
DC10957 MB725

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).

2230058-99-6
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