Home > Inhibitors & Agonists > Immunology/Inflammation > Toll-like Receptor (TLR)
Cat. No. Product name CAS No.
DC10276 C29 Featured

C29 is a potential TLR2 inhibitor.

363600-92-4
DC9169 Chloroquine diphosphate

Chloroquine diphosphate is an antimalarial drug and autophagy/lysosome inhibitor; inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs).

50-63-5
DC10771 CU-CPT-8m Featured

CU-CPT-8m is a nolve TLR8 inhibitor.

125079-83-6
DC10769 CU-CPT-9a Featured

CU-CPT-9a is a nolve TLR8 inhibitor.

2162962-69-6
DC10770 CU-CPT-9b Featured

CU-CPT-9b is a nolve TLR8 inhibitor.

2165340-32-7
DC7609 Isatoribine

Isatoribine is a selective agonist of TLR7

122970-40-5
DC7305 TAK-242 (Resatorvid)

TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.

243984-11-4
DC10963 TLR7 and 8 modulator 31

TLR7 and 8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively.

1413944-59-8
DC28230 Loxoribine

Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.

121288-39-9
DC28265 DSR-6434

DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect.

1059070-10-8
DC28274 CU-T12-9

CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.

1821387-73-8
DC28351 1V209(TLR7 agonist T7) Featured

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity.

1062444-54-5
DC28386 GSK2245035

GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma.

1207629-49-9
DC28692 TLR7/8 agonist 3

TLR7/8 agonist 3 is a potent TLR7 and TLR8 agonist, extracted from patent US20170114137A1.

642473-95-8
DC28932 Polyinosinic-polycytidylic acid sodium

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.

42424-50-0
DC29107 Pam3CSK4

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.

112208-00-1
DC29108 Pam3CSK4 TFA

Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.

112208-01-2
DC29112 Pam3CSK4-Biotin

Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist.

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