Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Nucleoside Antimetabolite/Analog
Cat. No. Product name CAS No.
DCAPI1525 5-Azacytidine

5-Azacytidine is a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (Dnmt), forming covalent adducts with cellular DNMT1 depleting enzyme activity. 5-Azacytidine also improves t

320-67-2
DC8944 5-Fluorouracil

5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.

51-21-8
DC11851 Clitocine

A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent.

105798-74-1
DC10318 Acelarin(NUC1031) Featured

Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.

840506-29-8
DC9799 CNDAC Featured

CNDAC is the active component of sapacitabine.

135598-68-4
DC11192 Elacytarabine

Elacytarabine (CP-4055, CP4055) is a fatty acid derivative of cytarabine with potential antineoplastic activity.

188181-42-2
DC2108 Gemcitabine free base

Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites.

95058-81-4
DC10332 MT-DADMe-ImmA

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.

653592-04-2
DC8940 Raltitrexed

Raltitrexed(ZD1694), an inhibitor of thymidylate synthase, is an antimetabolite drug used in cancer chemotherapy.

112887-68-0
DC7762 RX-3117

RX-3117 is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity.

865838-26-2
DC10444 Sapacitabine (CYC682) Featured

Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity.

151823-14-2
DC8962 Tegafur

Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.

17902-23-7
DC8758 Tipiracil hydrochloride Featured

Tipiralacil(TPI) is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.

183204-72-0
DC7522 Triapine Featured

Triapine is a potent ribonucleotide reductase inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.

143621-35-6
DC9419 Zebularine

Zebularine(NSC309132; 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM.

3690-10-6
DC28958 Plevitrexed

Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical.

153537-73-6
DC28960 (Rac)-Plevitrexed

(Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331) is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor.

153538-08-0
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