Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > TRP Channel
Cat. No. Product name CAS No.
DCL-011 Capsaicin

>98%,Standard References

2444-46-4
DC11502 2-APB

A membrane permeable IP3 receptor antagonist and broad TRP channels (TRPC5, TRPM2) blcoker.

524-95-8
DC12018 MRS 1477

A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).

212200-21-0
DC11508 AC1903

AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.

831234-13-0
DC11239 AMG-333 Featured

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

1416799-28-4
DC7055 AMG517 Featured

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

659730-32-2
DC10132 AMG9810 Featured

AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM).

545395-94-6
DC10558 ASP 7663 Featured

ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat).

1190217-35-6
DC9826 BCTC Featured

BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.

393514-24-4
DC7387 Clemizole Hydrochloride Featured

Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

1163-36-6
DC8832 Clemizole (free base) Featured

Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

442-52-4
DC11280 GSK1016790A Featured

GSK1016790A is a novel and potent TRPV4 channel agonist.

942206-85-1
DC10865 GSK2193874 Featured

GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50 of 2 nM and 40 nM for rTRPV4 and hTRPV4.

1336960-13-4
DC11416 HC-067047 Featured

HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM).

883031-03-6
DC7213 ICILIN Featured

Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.

36945-98-9
DC8378 Mavatrep(JNJ-39439335) Featured

Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.

956274-94-5
DC7998 ML 204 Featured

ML 204 isa blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively).

5465-86-1
DC7262 Optovin Featured

Optovin is a reversible photoactive TRPA1 activator.

348575-88-2
DC10399 PAC-14028

PAC-14028 is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.

1005168-10-4
DC9636 Pyr6

Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).

245747-08-4
DC11325 RN-1734

RN-1734 is a transient receptor potential vanilloid 4 (TRPV4) antagonist, blocking calcium influx induced by the TRPV4 agonist 4α-phorbol 12,13-didecanoate with IC50 values of 2.3, 5.9, and 3.2 µM for human, mouse, and rat TRPV4, respectively.

946387-07-1
DC8306 RQ-00203078 Featured

RQ-00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).

1254205-52-1
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