Cat. No. | Product name | CAS No. |
DC11868 |
Freselestat
A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM. |
208848-19-5 |
DC11857 |
BAY-8040 (R)
Featured
Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension. |
1194453-23-0 |
DC11858 |
BAY-678
A potent, selective, cell permeable human neutrophil elastase inhibitor with IC50 of 20 nM. |
675103-36-3 |
DC11859 |
BAY85-8501
BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM. |
1161921-82-9 |
DC9434 |
DMP 777
DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. |
157341-41-8 |
DC8592 |
Sivelestat (sodium salt hydrate)
Featured
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
201677-61-4 |
DC29003 |
FK706
FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect. |
144055-55-0 |
DC41083 |
Freselestat quarterhydrate
Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity. |
|
DC41120 |
AE-3763
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM. |
291778-77-3 |