Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Elastase
Cat. No. Product name CAS No.
DC11868 Freselestat

A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.

208848-19-5
DC11857 BAY-8040 Featured

Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.

1194453-23-0
DC11858 BAY-678

A potent, selective, cell permeable human neutrophil elastase inhibitor with IC50 of 20 nM.

675103-36-3
DC11859 BAY85-8501

BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM.

1161921-82-9
DC9434 DMP 777

DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

157341-41-8
DC8592 Sivelestat (sodium salt hydrate)

Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.

201677-61-4
DC29003 FK706

FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect.

144055-55-0
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