Home > Inhibitors & Agonists > GPCR > mAChR
Cat. No. Product name CAS No.
DC11748 LY2033298

A potent, selective, positive allosteric modulator of muscarinic M4 receptors.

886047-13-8
DC10293 AC260584

AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6.

560083-42-3
DC11747 Iperoxo

An extremely potent muscarinic receptor agonist with EC50 of 2.12 nM and 8.47 nM for M2 and M4, respectively.

247079-84-1
DC10731 Arecaidine but-2-ynyl ester tosylate Featured

Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum.

119630-77-2
DC10021 Batefenterol Featured

Batefenterol(GSK961081,TD-5959)is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA).

743461-65-6
DCAPI1702 Diphemanil Methylsulfate Featured

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

62-97-5
DC10039 DREADD Agonist 21 Featured

DREADD agonist 21 is a potent muscarinic hM3Dq DREADD agonist (EC50 = 1.7 nM). Highly selective for hM3Dq DREADDs over endogenous hM3 receptors.

56296-18-5
DC8912 Fesoterodine fumarate

Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.

286930-03-8
DC8779 Glycopyrrolate

Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.

596-51-0
DC8435 LY2119620

LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

886047-22-9
DC11111 PF-06764427

PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM.

1842371-08-7
DC11116 PF-06827443

PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.

2115022-67-6
DC10012 Pirmenol hydrochloride Featured

Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.

61477-94-9
DC11208 TAK-071 Featured

TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.

1820812-16-5
DC7932 TBPB Featured

TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.

634616-95-8
DC8813 TD-4208 Featured

TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction.

864750-70-9
DCAPI1449 Tiotropium Bromide Featured

Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.

136310-93-5
DCAPI1429 Tolterodine tartrate

Tolterodine L-Tartrate is a muscarinic receptor antagonist that is active at all mAChR M subtypes. This compound blocks the opening of ion channels by acetylcholine, which in turn leads to muscle relaxation by blocking neuronal signaling.

124937-52-6
DC8153 Umeclidinium bromide Featured

Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).

869113-09-7
DC12159 VU 0238429 Featured

VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

1160247-92-6
DC12165 VU 0365114

VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.

1208222-39-2
DC9497 VU0152100 Featured

VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.

409351-28-6
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