Home > Inhibitors & Agonists > JAK/STAT Signaling > STAT
Cat. No. Product name CAS No.
DC12010 ML116

A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).

744270-00-6
DC11882 HJC0416

A orally bioavailable small-molecule STAT3 inhibitor.

1617518-22-5
DC12009 CPA-7

A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.

16961-77-6
DC11420 AS-1517499

AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.

919486-40-1
DC8040 STAT3 Inhibitor XVIII, BP-1-102

BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor.

1334493-07-0
DC10864 C188-9

C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.

432001-19-9
DC10111 Debio 0617B

Debio 0617B has been developed as a first-in-class kinase inhibitor with a unique profile targeting phospho-STAT3 (pSTAT3) and/or pSTAT5 in tumors through combined inhibition of JAK, SRC, ABL, and class III/V receptor tyrosine kinases (RTK).

1332329-27-7
DC8726 FLLL31

FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.

52328-97-9
DC7751 FLLL32

FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor.

1226895-15-3
DC10626 HJC0152

HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.

1420290-99-8
DC10555 inS3-54A18

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

328998-53-4
DC8474 Napabucasin (BBI608)

Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells.

83280-65-3
DC9691 Piperlongumine

Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53.

20069-09-4
DC7983 SH-4-54

SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.

1456632-40-8
DC10105 SH5-07

SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9±0.6 μM in in vitro assay.

1456632-41-9
DC10139 Stat5 Inhibitor

Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain.

285986-31-4
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