Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Checkpoint Kinase (Chk)
Cat. No. Product name CAS No.
DC11718 Debromohymenialdisine

A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.

75593-17-8
DC11953 MU 380

A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2.

2109805-78-7
DC11715 PV-1115

A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM.

1093793-10-2
DC11654 VRX-0466617

A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM.

926906-64-1
DC11714 PV-1019

A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.

DC11717 PD-321852

A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.

622856-21-7
DC11710 GDC-0425

A potent, selective and orally active Chk1 inhibitor.

1200129-48-1
DC11711 VER-158411

A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.

1174664-88-0
DC11733 SAR-020106

A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM.

184843-57-9
DC11713 NSC-109555 ditosylate

A potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.

66748-43-4
DC11716 XL-844

A potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.

631864-00-1
DC7076 AZD 7762

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM; equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.

860352-01-8
DC9399 CCT241533 (hydrochloride)

CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM.

1431697-96-9
DC8324 CCT244747

CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies.

1404095-34-6
DC10485 GDC0575(ARRY-575,RG7441)

GDC0575(ARRY-575,RG7441)is a small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity.

1196541-47-5
DC11732 GNE-900

GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.

1200126-26-6
DC7103 LY2603618(IC-83)

LY2603618(IC-83) is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC50=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials.

911222-45-2
DC7993 Prexasertib (LY2606368) 2HCl

LY2606368 2Hcl is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase.

1234015-54-3
DC10796 Prexasertib (LY2606368)

LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase.

1234015-52-1
DC8259 PF0477736

PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity

952021-60-2
DC9792 SAR020106

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme.

1184843-57-9
DC9924 SB218078

SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively).

135897-06-2
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