Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Indoleamine 2,3-Dioxygenase (IDO)
Cat. No. Product name CAS No.
DC10131 BMS-986205(Linrodostat) Featured

BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial

1923833-60-6
DC8389 Epacadostat (INCB024360) Featured

Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2.

1204669-58-8
DC10098 IDO-IN-1 Featured

IDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM).

914638-30-5
DC10421 IDO-IN-2 Featured

IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.

1668565-74-9
DC7015 INCB024360 analogue(IDO-IN-1) Featured

INCB024360 is a potent IDO1 inhibitor(IC50=10 nM) with desirable pharmaceutical properties, which is poised to start clinical trials in cancer patients.

914471-09-3
DC8021 Indoximod (NLG-8189) Featured

NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2)

110117-83-4
DC10022 PF06840003 Featured

PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.

198474-05-4
DC11159 Roxyl-WL

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.

667887-37-8
DC28283 (Rac)-IDO1-IN-5

(Rac)-IDO1-IN-5 (Example 1) is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

2166616-74-4
DC28284 (S)-IDO1-IN-5

(S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

2166616-76-6
DC28673 IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.

2346614-58-0
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