Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > Sodium Channel
Cat. No. Product name CAS No.
DC9624 (-)-Sparteine (sulfate pentahydrate)

(-)-Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker.

6160-12-9
DCH-043 Tetrodotoxin

>98%,Standard References

4368-28-9
DC11984 AMG 8379

A potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM.

1642112-31-9
DC11490 A-317567

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.

371217-32-2
DC2061 A-803467

A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM.

944261-79-4
DC11289 AM-0466

AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.).

1642113-59-4
DC9909 AM2099

AM-2099 is a potent and selective NaV1.7 Inhibitor.

1443373-17-8
DC11649 AnCoA4

AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.

24211-36-7
DC9193 Carbamazepine

Carbamazepine, a sodium channel blocker, is an anticonvulsant drug.

298-46-4
DC7990 Cariporide

Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively).

159138-80-4
DC8095 Raxatrigine hydrochloride

CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

934240-31-0
DC9623 Flecainide (acetate)

Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

54143-56-5
DC10907 GNE-131

GNE-131 is a novel NaV1.7 inhibitor with IC50 0.003uM,improving metabolic stability,efficacy in mouse IEM model at C-plasma <2.8uM.

1629063-81-5
DC8006 GS967(GS-458967)

GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa).

1262618-39-2
DC8213 ICA-121431

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels.

313254-51-2
DC8124 ETH 2120(Sodium ionophore III)

Ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode.

81686-22-8
DC8797 Lacosamide

Lacosamide (Vimpat; Erlosamide) is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.

175481-36-4
DC8974 Mexiletine Hydrochloride

Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound.

5370-01-4
DC8666 Nav1.7-IN-2

Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.

1332295-35-8
DC9796 Nicainoprolhe

Nicainoprolhe is an antiarrhythmic agent,a fast-sodiumchannel blocking drug (class Ib), also protected isolated rat hearts against reperfusion arrhythmias.

76252-06-7
DC9001 Oxcarbazepine

Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

28721-07-5
DC10529 PF 05089771

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

1235403-62-9
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