Home > Inhibitors & Agonists > Tyrosine Kinase
Cat. No. Product name CAS No.
DCD-057 n-Butylidenephthalide

>98%,Standard References

551-08-6
DC9281 1-NA-PP1 Featured

1-Naphthyl PP1(1-NA-PP 1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).

221243-82-9
DC10889 1-NA-PP 1 hydrochloride Featured

1-Naphthyl PP1(1-NA-PP1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl.

956025-47-1
DC10215 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).

38183-03-8
DC11707 MDVN-1003

A first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.

2058116-54-2
DC11612 KBP-7018 hydrochloride

A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.

1613437-67-4
DC11611 KBP-7018

A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.

1613437-66-3
DC11916 FD-5180

A novel protein kinase affinity probe...

2098621-92-0
DC11954 JP-153

A novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.

1802937-26-3
DC11804 IQS-019

A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.

1630804-24-8
DC11805 IQS-019 mesylate

A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.

1630804-27-1
DC12007 SOMG-833

A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.

1268264-10-3
DC11721 PF-06747775

A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.

1776112-90-3
DC10922 AAE871

AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity..

289479-07-8
DC4231 Linifanib (ABT-869) Featured

ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families.

796967-16-3
DC9660 Acalabrutinib(ACP196) Featured

Acalabrutinib (ACP-196) is a second-generation, selective, irreversible inhibitor of BTK.

1420477-60-6
DC11512 Acrizanib Featured

Acrizanib(LHA510) is a potent and selective angiogenesis inhibitor and VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

1229453-99-9
DC10633 AD80

AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

1384071-99-1
DC5113 AEE-788 (NVP-AEE788) Featured

AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.

497839-62-0
DC3164 BIBW2992-MA2 (Afatinib dimaleate) Featured

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

850140-73-7
DC10589 AG 1406 Featured

AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 .

71308-34-4
DC8079 AG-1557 Featured

AG-1557 is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK).

189290-58-2
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