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Cat. No. Product name CAS No.
DC9482 17-AAG

17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.

75747-14-7
DC9793 AMG232

AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells .

1352066-68-2
DC6901 Daporinad(FK866,APO866)

APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM.

658084-64-1
DC1069 AZD6244 (Selumetinib,ARRY-142886) Featured

AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.

606143-52-6
DC10131 BMS-986205(Linrodostat) Featured

BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial

1923833-60-6
DC3102 GDC-0879 Featured

GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM.

905281-76-7
DC4177 Cobimetinib(GDC-0973; XL518) Featured

GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway.

934660-93-2
DC10098 IDO-IN-1 Featured

IDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM).

914638-30-5
DC8344 LY3009120 Featured

LY3009120 is a potent and selective pan-RAF inhibitor with potential anticancer activity.

1454682-72-4
DC8158 Pexidartinib(PLX3397) Featured

PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.

1029044-16-3
DC1071 Vemurafenib (PLX4032)

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

918504-65-1
DC6301 PLX-4720 Featured

PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.

918505-84-7
DC5049 RAF265 (CHIR-265)

RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf.

927880-90-8
DC1099 Trametinib Featured

Trametinib is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

871700-17-3
DC4232 Vismodegib (GDC-0449)

Vismodegib (formerly GDC-0449) is a hedgehog antagonist, is also an orally bioavailable small molecule with potential antineoplastic activity.

879085-55-9
DC7868 AS703026(Pimasertib)

AS703026(Pimasertib) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.

1236699-92-5
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