Home > Inhibitors & Agonists > Wnt/Notch/Hedgehog > Notch
Cat. No. Product name CAS No.
DC11489 6-alkynyl Fucose

A fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.

935658-91-6
DC11930 EDD3

A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes.

25279-15-6
DC11862 BMS-906024

BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.

1401066-79-2
DC9756 IMR-1 Featured

IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

310456-65-6
DC9785 IMR-1A Featured

IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.

331862-41-0
DC7776 LY-3039478

LY3039478 a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.

1421438-81-4
DC11017 ZLDI-8

ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus.

667880-38-8
DC28774 CB-103

CB-103 is a notch signaling pathway inhibitor extracted from patent US9296682B2. CB-103 is developed for the treatment of cancers.

218457-67-1
Page 1 / Total 1 FirstPrevNextLastGoto