Home > Inhibitors & Agonists > Ras-Raf-MAPK-ERK > p38 MAPK
Cat. No. Product name CAS No.
DC10417 Acumapimod

Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.

836683-15-9
DC7836 Doramapimod (BIRB-796)

BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.

285983-48-4
DC7711 Losmapimod

Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.

585543-15-3
DC8630 Ralimetinib 2MsOH(LY2228820)

LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively).

862507-23-1
DC11829 MW-150

MW-150 is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM

1628502-91-9
DC11828 MW-150 hydrochloride

MW-150 is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM

1923773-01-6
DC9681 Pamapimod(R-1503) Featured

Pamapimod(R-1503)is a novel p38 MAP kinase inhibitor.

449811-01-2
DC5095 PD169316 Featured

PD169316 is a potent and selective p38 MAP kinase inhibitor

152121-53-4
DC7491 RWJ67657 Featured

RWJ67657 is a selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases.

215303-72-3
DC2097 SB202190 Featured

SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway.

152121-30-7
DC7807 SB 239063

SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.

193551-21-2
DC1004 SB-203580 Featured

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM.

152121-47-6
DC8255 SD-06

SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).

271576-80-8
DC7946 SKF-86002 Featured

SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).

72873-74-6
DC9300 TA-02 Featured

TA-02 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively).

1784751-19-4
DC7304 TAK 715

TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.

303162-79-0
DC1061 VX-702 (VX702)

VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM.

745833-23-2
DC4173 VX-745

VX-745 is a potent and selective inhibitor of p38α MAPK and p38β MAPK with IC50 of 10 nM and 220 nM, respectively.

209410-46-8
DC7028 SB242235 Featured

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.

193746-75-7
DC28527 Muramyl dipeptide

Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio.

53678-77-6
DC28915 SR-318

SR-318 is a potent and highly selective p38 MAP kinase inhibitor with IC50s of 5 nM, 32nM and 6.11 μM for p38α, p38βand p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity.

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