Home > Inhibitors & Agonists > Nuclear Receptor/Transcription Factor > HIF/HIF Prolyl-hydroxylase
Cat. No. Product name CAS No.
DC9044 2-Methoxyestradiol

2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.

362-07-2
DC11607 JTZ-951

A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

1262132-81-9
DC11608 JTZ-951 hydrochloride

A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

1262131-60-1
DC8188 Daprodustat

Daprodustat(GSK1278863) isa HIF-prolyl hydroxylase inhibitor.

960539-70-2
DC11402 Desidustat

Desidustat is an inhibitor of HIF hydroxylase.

1616690-16-4
DC8195 FG2216

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.

223387-75-5
DC5193 Roxadustat(FG-4592)

FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production.

808118-40-3
DC8166 Molidustat(BAY 85-3934)

Hypoxia-inducible factor prolyl hydroxylase inhibitor

1154028-82-6
DC11782 IDF-11774

IDF-11774 is a novel hypoxia-inducible factor α (HIFα)-1 inhibitor with an IC50 of 3.65 μM.

1429054-28-3
DC10825 IOX4

IOX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM).

1154097-71-8
DC8617 JNJ-42041935

JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.

1193383-09-3
DC8447 KC7F2

KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study.

927822-86-4
DC12043 KHS-101

KHS101 is a selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM).

1262770-73-9
DC7683 ML-228

ML-228 is a hIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD.

1357171-62-0
DC8390 Oltipraz

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

64224-21-1
DC10464 PT2385

PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity.

1672665-49-4
DC9811 PT2399

PT2399(PT=2399) is a novel HIF2α Antagonist.

1672662-14-4
DC7486 PX-478 2HCL

PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells.

685898-44-6
DC10436 SYP-5

SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.

1384268-04-5
DC10339 Vadadustat

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

1000025-07-9
DC28630 HIF-2α-IN-2

HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC50 of 16 nM in scintillation proximity assay (SPA).

1672666-82-8
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