AMG-837

  Cat. No.:  DC7867  
AMG-837
Chemical Structure
865231-46-5
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More than 5000 active chemicals with high quality for research!
Field of application
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
Cas No.: 865231-46-5
Chemical Name:
Synonyms: AMG-837; AMG837
SMILES: OC(C[C@H](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O
Formula: C26H21F3O3
M.Wt: 438.44
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively). AMG 837 was found to be a partial agonist on GPR40 with maximal activity 85% of that shown by DHA under our standard assay conditions. AMG 837 is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. showed no significant activity in cell-based assays against PPARα, δ, and γ. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50 = 3 uM) on the a2-adrenergic receptor. Overall, AMG 837 was both highly potent and selective in vitro.For the detailed information of AMG-837, the solubility of AMG-837 in water, the solubility of AMG-837 in DMSO, the solubility of AMG-837 in PBS buffer, the animal experiment (test) of AMG-837, the cell expriment (test) of AMG-837, the in vivo, in vitro and clinical trial test of AMG-837, the EC50, IC50,and affinity,of AMG-837, Please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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