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Cell Cycle/DNA Damage

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Cat. No. Product Name Field of Application Chemical Structure
DC46669 5'-O-DMT-2'-O-TBDMS-Ac-rC
5'-O-DMT-2'-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
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DC46668 2'-OMe-G(ibu) Phosphoramidite
2'-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
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DC46667 2'-O-Me-C(Bz) Phosphoramidite
2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
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DC46666 2'-OMe-A(Bz) Phosphoramidite
2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
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DC46635 dGTP
dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
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DC46634 Deoxythymidine-5'-triphosphate
Deoxythymidine-5'-triphosphate (dTTP), a deoxynucleotide, can be used in deoxyribonucleic acid synthesis.
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DC46633 7-TFA-ap-7-Deaza-ddG
7-TFA-ap-7-Deaza-ddG (compound 19d, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.
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DC46632 7-TFA-ap-7-Deaza-ddA
7-TFA-ap-7-Deaza-ddA (compound 19c, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.
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DC46631 7-Deaza-2',3'-dideoxyadenosine
7-Deaza-2',3'-dideoxyadenosine can be used in the synthesis of oligodeoxyribonucleotides.
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DC46630 5'-O-TBDMS-N2-ibu-dG
5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity.
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DC46629 5'-O-TBDMS-dU
5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.
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DC46628 5'-O-DMT-N6-ibu-dA
5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides.
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DC46627 5'-O-DMT-ibu-dC
5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
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DC46626 2'-F-Bz-dC Phosphoramidite
2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotides.
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DC46607 [pSer2, pSer5, pSer7]-CTD TFA
[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD).
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DC46599 Cycloguanil D6
Cycloguanil D6 is the deuterium labeled Cycloguanil, which is a dihydrofolate reductase inhibitor.
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DC46545 Ac-dA Phosphoramidite
Ac-dA Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
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DC46544 7-TFA-ap-7-Deaza-dA
7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
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DC46543 7-TFA-ap-7-Deaza-dG
5'-O-TBDMS-dG is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
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DC46542 5'-O-DMT-N6-Me-2'-dA
5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.
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DC46541 5'-O-DMT-N2-DMF-dG
5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
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DC46540 5'-O-DMT-2'-O-TBDMS-rI
5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
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DC46539 5'-O-DMT-2'-O-TBDMS-Bz-rC
5'-O-DMT-2'-O-TBDMS-Bz-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
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DC46538 2-Amino-2'-deoxyadenosine
2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.
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DC46526 5-Iminodaunorubicin
5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells.
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DC46497 CDK8-IN-1
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
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DC46480 RKI-1447 dihydrochloride
RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis.
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DC46470 CPS2
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50= 24 nM). CPS2 can be used for the research of acute myeloid leukemia.
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DC46459 3-Methylthienyl-carbonyl-JNJ-7706621
3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective inhibitor of cyclin-dependent kinase (CDK), with IC50s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. 3-Methylthienyl-carbonyl-JNJ-7706621 also shows potent inhibition of GSK-3 (IC50=0.041 μM) and modest potency against CDK4, VEGF-R2, and FGF-R2 (IC50=0.11, 0.13, 0.22 μM, respectively). 3-Methylthienyl-carbonyl-JNJ-7706621 can be used for the research of cancer.
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DC46441 CDK12-IN-6
CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1).
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