11R-VIVIT (NFAT inhibitor)|CAS 592517-80-1|DC Chemicals

Cas No.:	592517-80-1
Chemical Name:	11R-VIVIT
Synonyms:	RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
Formula:	C₁₄₇H₂₅₉N₆₇O₃₆S
M.Wt:	3573.15
Purity:	>95%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

11R-VIVIT is a potent NFAT inhibitor. 11R-VIVIT inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). 11R-VIVIT also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. 11R-VIVIT improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice.

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