Cat. No. | Product name | CAS No. |
DC7113 |
CZC-25146
Featured
CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. |
1191911-26-8 |
DC8082 |
CZC-54252
Featured
CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). |
1191911-27-9 |
DC7418 |
DNL201
Featured
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. |
1374828-69-9 |
DC7419 |
GNE-7915
Featured
GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). |
1351761-44-8 |
DC7629 |
GNE-9605
Featured
GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor |
1536200-31-3 |
DC7852 |
LRRK2 inhibitor GSK2578215A
Featured
GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. |
1285515-21-0 |
DC8379 |
JH-II-127
Featured
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
1700693-08-8 |
DC11440 |
LRRK2 inhibitor 18
Featured
LRRK2 inhibitor 18(Compound 18) is a potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 4.1 nM. |
1459257-24-9 |
DC8237 |
LRRK2-IN-1
Featured
LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13 nM and 6 nM , respectively with 0.1 mM ATP in the assay. |
1234480-84-2 |
DC10360 |
MLi-2
Featured
MLi-2 is an a potent, highly selective, orally available, brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM. |
1627091-47-7 |
DC7971 |
PF-06447475
Featured
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. |
1527473-33-1 |
DC11288 |
PF-06454589
Featured
PF-06454589 is a potent and selective LRRK2 inhibitor. |
1527473-30-8 |
DC9496 |
HG-10-102-01
Featured
HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM) |
1351758-81-0 |
DC44941 |
CZC-54252 hydrochloride
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity. |
1784253-05-9 |
DC48117 |
EB-42486
Featured
EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM). |
2390475-81-5 |
DC49541 |
LRRK2-IN-3
LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease. |
2641054-60-4 |
DC49542 |
LRRK2-IN-2
LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of <0.6 nM. LRRK2-IN-2 can be used for the research of Parkinson's disease. |
2641059-19-8 |
DC70422 |
G2019S-LRRK2 inhibitor 38
G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice. |
2704564-03-2 |
DC71101 |
PF-06456384
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research. |
1834610-73-9 |
DC72017 |
XL01126
XL01126 is a potent degrader of LRRK2 with DC50s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research. XL01126 exerts function of study of non-catalytic and scaffolding functions of LRRK2. |
|
DC72311 |
PF-06455943
PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD). |
1527474-15-2 |
DC73143 |
BIIB122
BIIB122 (DNL151) is a potent, selective, CNS-penetrant LRRK2 inhibitor. |