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Fibrosis

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Cat. No. Product Name Field of Application Chemical Structure
DC11678 Galicaftor Featured
Galicaftor (ABBV-2222/GLPG-2222) is an orally bioavailable small molecule that functions as a CFTR corrector, demonstrating potential for therapeutic development in cystic fibrosis research.
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DC9278 CWHM-12 Featured
CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.
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DC10390 TD139 Featured
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM.
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DC4128 Ivacaftor (VX-770) Featured
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
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DC11803 GLPG-1690(Ziritaxestat) Featured
GLPG-1690 is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM.
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DC10459 BMS-986020 Featured
BMS-986020 is an LPA1 antagonist.
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DC1059 Lumacaftor(vx-809,vx809) Featured
VX-809 is a CFTR modulator with EC50 of 0.1 μM.
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DC11518 Cavosonstat Featured
Cavosonstat is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.
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DC9986 Acebilustat(ZK322) Featured
Acebilustat(ZK322) is a potent and selective leukotriene A4 hydrolase inhibitor.
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DC10753 GLPG-1837(ABBV-974) Featured
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
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DC11099 PBI-4050
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
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DC11100 PBI-4050 sodium
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
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DC11096 Olacaftor
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis..
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DC9434 DMP 777
DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
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