Cat. No. | Product Name | Field of Application | Chemical Structure |
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DC11678 | Galicaftor Featured |
Galicaftor (ABBV-2222/GLPG-2222) is an orally bioavailable small molecule that functions as a CFTR corrector, demonstrating potential for therapeutic development in cystic fibrosis research.
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DC9278 | CWHM-12 Featured |
CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.
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DC10390 | TD139 Featured |
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM.
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DC4128 | Ivacaftor (VX-770) Featured |
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
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DC11803 | GLPG-1690(Ziritaxestat) Featured |
GLPG-1690 is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM.
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DC10459 | BMS-986020 Featured |
BMS-986020 is an LPA1 antagonist.
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DC1059 | Lumacaftor(vx-809,vx809) Featured |
VX-809 is a CFTR modulator with EC50 of 0.1 μM.
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DC11518 | Cavosonstat Featured |
Cavosonstat is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.
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DC9986 | Acebilustat(ZK322) Featured |
Acebilustat(ZK322) is a potent and selective leukotriene A4 hydrolase inhibitor.
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DC10753 | GLPG-1837(ABBV-974) Featured |
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
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DC11099 | PBI-4050 |
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
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DC11100 | PBI-4050 sodium |
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
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DC11096 | Olacaftor |
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis..
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DC9434 | DMP 777 |
DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
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