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| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC48418 | SR15006 Featured |
SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells).
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| DC73843 | NC114 |
NC114 is a small molecule targeting cancer-associated KLF5 transcription factor, decreases the KLF protein but not mRNA levels of KLF in vitro.
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| DC9682 | ML-264 Featured |
ML264 is a novel small molecule inhibitor of Krüppel-like factor 5 (KLF5).
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| DC39108 | SR18662 Featured |
SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis.
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| DC11822 | YD-277 |
A novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM.
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