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Cat. No. Product name CAS No.
DC11620 RIPK2-IN-8

A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.

DC10787 GSK2982772 Featured

GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM.

DC9721 GSK2983559 active metabolite Featured

GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

DC9733 GSK583 Featured

GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM).

DC10471 GSK-872 Featured

GSK-872 is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor.

DC12045 HS-1371 Featured

HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis.

DC10389 RIPA-56 Featured

RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.

DC10373 WEHI-345 Featured

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.

DC28704 RIP2 kinase inhibitor 1

RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders.

DC40776 Necroptosis-IN-1

Necroptosis-IN-1, an analog of Necrostatin-1 (HY-15760), is a potent necroptosi inhibitor. Necroptosis-IN-1 is a RIPK inhibitor.

DC44123 RIPK3-IN-1

RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM.

DC45531 ICCB-19 hydrochloride Featured

ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.

DC46824 Eclitasertib

Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 of <1 µΜ (From patent WO2017136727A2, example 42).

DC46825 GSK-872 hydrochloride

GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

DC47267 RIP2 Kinase Inhibitor 4

RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α.

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