Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > ROCK
Cat. No. Product name CAS No.
DC8567 3-(4-Pyridyl)

3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay

7272-84-6
DC10860 BDP5290 Featured

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

1817698-21-7
DC7413 Fasudil-HA Featured

Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.

105628-07-7
DC7249 ROCK inhibitor GSK269962A Featured

GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.

850664-21-0
DC7144 GSK429286A Featured

GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.

864082-47-3
DC9614 Hydroxyfasudil (hydrochloride) Featured

Hydroxyfasudil Hcl(HA1100 Hcl), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.

155558-32-0
DC7774 Ripasudil(K-115) Featured

K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension.

887375-67-9
DC12203 Pentanoic acid

Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway.

109-52-4
DC8185 Verosudil(AR-12286)

Rho-kinase (ROCK) inhibitor

1414854-42-4
DC8831 RKI-1313 Featured

RKI-1313 is the negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer

1342276-76-9
DC7269 RKI-1447 Featured

RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.

1342278-01-6
DC8104 SAR407899 HCl

SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.

923262-96-8
DC9854 SAR407899 Featured

SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.

923359-38-0
DC8329 SLx-2119(KD-025,Belumosudil ) Featured

SLx-2119(KD-025) is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM)

911417-87-3
DC7246 SR3677 Featured

SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM.

1072959-67-1
DC6902 Thiazovivin Featured

Thiazovivin is a rock inhibitor and enhances fibroblast reprogramming efficiency to generate stem cells

1226056-71-8
DC1028 Y-27632 2HCL Featured

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM.

129830-38-2
DC10167 ZINC00881524

ZINC00881524 is a ROCK inhibitor.

557782-81-7
DC41080 Chroman 1 dihydrochloride

Chroman 1 dihydrochloride is a highly potent ROCK2 inhibitor, with an IC50 of 1 nM. Chroman 1 dihydrochloride also shows inhibitory activities against MRCK, with an IC50 of 150 nM.

DC41914 Exoenzyme C3, clostridium botulinum

Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration.

58319-92-9
DC45269 H-1152 dihydrochloride

H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

871543-07-6
DC45762 Y-27632 Featured

Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

146986-50-7
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