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Enzymes substrates

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Cat. No. Product Name Field of Application Chemical Structure
DC60824 Ac-LETD-AFC Featured
Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism.
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DC60823 Ac-ATAD-AFC(Caspase-12 Substrate) Featured
Ac-ATAD-AFC(Caspase-12 Substrate) is a fluorogenic substrate for caspase-12.
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DC11455 Bz-Ile-Glu-Gly-Arg-pNA HCl(S222,FXa substrate) Featured
S-2222 (Bz-Ile-Glu-Gly-Arg-pNA HCl) is a chromogenic substrate specifically designed for the detection and measurement of Factor Xa activity.
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DC11454 Gly-Pro-pNA(chromogenic substrate) Featured
Gly-Pro-pNA is a chromogenic substrate specifically cleaved by dipeptidyl peptidase IV (DPP IV), an enzyme present in circulation. The enzymatic activity can be measured colorimetrically by detecting the release of p-nitroanilide at 405 nm. DPP IV plays a critical role in inactivating two key peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), which are essential for nutrient-stimulated insulin secretion. This substrate is particularly useful for screening DPP IV inhibitors, which are being explored as potential antidiabetic therapeutics.
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DC60339 Cephalofurimazine (CFz) Featured
Cephalofurimazine (CFz) is a NanoLuc substrate optimized for enhanced brain performance. When paired with Antares luciferase, it generates over 20 times more signal from the brain compared to the traditional combination of D-luciferin and firefly luciferase.
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DC74576 Fluorofurimazine Featured
Fluorofurimazine is an advanced furimazine derivative with enhanced aqueous solubility, allowing for greater signal output compared to furimazine in bioluminescence imaging. This compound supports higher substrate concentrations and delivers improved sensitivity for in vivo optical imaging applications.
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DC45184 Hydrofurimazine Featured
Hydrofurimazine is a NanoLuc substrate whose enhanced aqueous solubility allows delivery of higher doses to mice. Hydrofurimazine enables sensitive bioluminescence imaging for either prolonged light production of high sensitivity.
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DCC5420 Viviren Featured
ViviRen is a synthetic analog of coelenterazine specifically designed for bioluminescence imaging (BLI), offering enhanced performance in visualizing biological processes.
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DC47169 pyCTZ TFA Featured
pyCTZ (Pyridyl CTZ) TFA, a pyridyl-modified derivative of Coelenterazine (CTZ), serves as an ATP-independent substrate for LumiLuc luciferase. This compound produces intense blue bioluminescence upon interaction with luciferases and is particularly effective in aequorin-based calcium sensing applications.
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DC42623 Furimazine Featured
Furimazine, an imidazopyrazinone-based substrate, generates exceptionally bright luminescence when paired with NanoLuc (Nluc). This combination produces a 2.5 million-fold increase in light output compared to the Oluc-19 and Coelenterazine system in mammalian cells.
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DC8863 Coelenterazine Featured
Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.
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DCC1510 Coelenterazine E Featured
Coelenterazine E serves as a bioluminescent probe, widely utilized for its ability to emit light in biological and chemical applications.
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DC82050 Coelenterazine H Featured
Coelenterazine h, a modified form of Coelenterazine, exhibits heightened sensitivity to Ca2+ compared to the native compound, making it an effective tool for detecting subtle fluctuations in Ca2+ concentrations.
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DC47168 pyCTZ hydrochloride Featured
pyCTZ (Pyridyl CTZ) hydrochloride, a pyridyl derivative of Coelenterazine (CTZ), functions as an ATP-independent substrate for LumiLuc luciferase. This compound produces intense blue bioluminescence when interacting with luciferases and is particularly useful in aequorin-based calcium sensing applications.
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DC49996 Coelenteramine 400a Featured
Coelenteramine 400a (Bisdeoxycoelenterazine), a structural analog of Coelenterazine, serves as a substrate for Renilla luciferase (RLuc). When interacting with Coelenteramine 400a, RLuc catalyzes the emission of blue light with a peak wavelength of 395 nm.
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DC40320 H-D-Phe-Pip-Arg-pNA hydrochloride(thrombinSubstrate, S-2238) Featured
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform.
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DC9807 Z-D-Arg-Gly-Arg-pNA (hydrochloride)(S-2765,chromogenic substrate) Featured
Z-D-Arg-Gly-Arg-pNA is a colorimetric substrate for Factor Xa.Factor Xa preferentially binds to and cleaves the Arg-Gly-Arg (RGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.
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DC72431 For-Met-Leu-pNA(N-formylated peptide substrate) Featured
For-Met-Leu-pNA is an N-formylated peptide substrate specifically designed for use in deformylase activity assays, providing a reliable tool for studying enzyme function.
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DC72410 Ac-Phe-Gly-pNA(chymotrypsin substrate) Featured
Ac-Phe-Gly-pNA is a synthetic peptide substrate specifically tailored for detecting chymotrypsin activity, offering high specificity for this enzyme.
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DC71896 Z-Gly-Pro-pNA(prolyl endopeptidase substrate) Featured
Z-Gly-Pro-pNA is a synthetic peptide substrate specifically designed for assessing the inhibitory activity of prolyl endopeptidase (PEP), making it a useful tool in enzymatic studies.
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DC41802 RETF-4NA TFA(chymase substrate) Featured
RETF-4NA TFA, a highly sensitive and selective substrate for chymase, effectively measures chymase activity both in its free form and when complexed with α2-macroglobulin (α2M). Its specificity makes it a valuable tool for studying chymase-related biochemical processes.
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DC71617 Suc-Gly-Gly-Phe-pNA(chymotrypsin substrate) Featured
The synthetic peptide Suc-Gly-Gly-Phe-pNA serves as a specific substrate for the enzyme chymotrypsin, demonstrating a Michaelis constant (Km) of 1.6 mM. This value reflects the substrate concentration at which the enzyme achieves half of its maximum reaction rate, indicating its affinity for the peptide.
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DC67293 D-Val-Gly-Arg-pNA Featured
D-Val-Gly-Arg-p-nitroaniline (D-VGR-pNA)​ is a synthetic chromogenic peptide substrate specifically designed for assessing the enzymatic activity of tissue plasminogen activator (tPA), including its isoforms tPA I and tPA II. Upon cleavage by tPA, the release of p-nitroaniline (pNA) generates a measurable colorimetric signal, enabling precise quantification of amidolytic activity. This substrate is widely utilized in biochemical assays to study tPA’s role in fibrinolysis and to evaluate its enzymatic kinetics in both research and diagnostic applications.
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DC20235 Ac-WEHD-pNA(substrate for caspase-1 and caspase-4) Featured
Ac-WEAD-pNA is a colorimetric substrate for caspase-1 and caspase-4.
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DC11458 Ac-DEVD-pNA(Caspase-3 Substrate) Featured
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.
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DC11350 AC-IETD-PNA (Caspase-8 Chromogenic Substrate) Featured
Ac-IETD-pNA is a substrate for caspase-8.Caspase-8 preferentially binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
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